Earticle

초록

영어

Functional regulation of a specific tissue or organ is controlled by a number of ways, including local cell‐gcell interaction. Of several forms of cell‐gcell junctional complexes, gap junctions are caught a great attention due to a formation of direct linkage between neighboring cells. Gap junctions are consisted of connexin (Cx) isoforms. In the present study, we evaluated expressional profiling of Cx isoforms in the rat initial segment (IS) of the male reproductive tract at different postnatal ages. The presence and expression of 13 Cx isoform mRNAs were determined by semi‐gquantitative real‐gtime PCR analyses. A total of 8 Cx isoform mRNAs were detected in the IS of the male rats during postnatal development. The highest level of Cx30.3 mRNA was found at 5 months of age, while abundance of Cx31 mRNA was the highest at 1 year of age. Expression of Cx31.1 gene was relatively consistent during the postnatal development. Fluctuation of Cx32 and 37 gene expression was observed during the postnatal period. Significant elevation of Cx40 mRNA abundance was detected at 25 days of age and older ages. Expression patterns of Cx43 and 45 genes were similar with the highest level at 2 weeks of age, followed by gradual decreases at older ages. These results indicate differential regulation on expression of Cx isoforms in the rat IS during postnatal development. A complicated regulation of gene expression of Cx isoforms in the IS at different postnatal ages is suggested.

목차

ABSTRACT
 INTRODUCTION
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 REFERENCES

키워드

저자

• Hee-Jung Seo [ Department of Biochemistry and Molecular Biology and Eulji University Medical Sciences Research Institute School of Medicine, Eulji University, Daejeon 310-746, Korea ]
• Chan-Wook Seon [ Department of Biochemistry and Molecular Biology and Eulji University Medical Sciences Research Institute, ]
• Inho Choi [ School of Biotechnology, Yeungnam University, Gyeongsan 712-749, Korea ]
• Yong-Pil Cheon [ School of Life Sciences and Chemistry, Institute of Basic Sciences, Sungshin Women’s University, Seoul 136-742, Korea ]
• Tae-Hoon Cheon [ School of Life Sciences and Biotechnology, Division of Life Sciences, Korea University, Seoul 136-701, Korea ]
• Ki-Ho Lee [ Department of Biochemistry and Molecular Biology and Eulji University Medical Sciences Research Institute School of Medicine, Eulji University, Daejeon 310-746, Korea ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Reproductive & developmental biology

• 간기

  계간

• pISSN

  1738-2432

• eISSN

  2288-0151

• 수록기간

  1977~2018

• 십진분류

  KDC 527 DDC 636