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Effect of Streptozotocin-Induced Diabetes on Bone and Heart Development in Juvenile Rats

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  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    Reproductive & developmental biology 바로가기
  • 통권
    Volume 34 No 2 (2010.06)바로가기
  • 페이지
    pp.81-88
  • 저자
    Joo-Heon Kim, Youngjeon Lee, Sangun Lee, Takao Suzuki, Sang-Kil Lee, Taeyoung Kang, Yonggeun Hong
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A123400

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원문정보

초록

영어
Our objective of current study was to investigate the development of bone and heart in association with diabetes mellitus (DM). DM was induced by administering an intraperitoneal injection of streptozotocin (STZ; 60 mg/kg) to 4‐gweek‐gold Sprague‐gDawley rats. Body weight and blood glucose were monitored, and rats were sacrificed after 2 or 5 weeks. The left ventricle (LV), including the interventricular septum, was weighed, and body weight and tibial bone length were assessed. Young diabetic rats showed reduced growth in terms of tibial length and body weight compared to controls. Moreover, diabetic males showed more significant growth suppression and reduced LV size than diabetic females. Morphometric analysis of tibiae from diabetic rats revealed suppressed bone growth at 2 and 5 weeks, with no difference between genders. STZ‐ginduced diabetes decreased bone growth and retarded pre‐gpubertal heart development. As a result, diabetes may increase cardiovascular risk factors and lead to eventual heart failure. Therefore, new therapeutic approaches are required for diabetic children exhibiting growth retardation. Heart growth factor, exercise, and cardiopulmonary physical therapy may be required to promote heart development and physiological function.

목차

ABSTRACT
 INTRODUCTION
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 REFERENCES

키워드

Diabetes Growth retardation Hypertrophy Streptozotocin(STZ) Tibial bone length

저자

  • Joo-Heon Kim [ Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Korea ]
  • Youngjeon Lee [ Deaprtment of Rehabilitation Science in Interdisciplinary PhD Program, Graduate School of Inje University, Gimhae 621-749, Korea ]
  • Sangun Lee [ Department of Physical Therapy, Aomori University of Health and Welfare, Aomori 030-8505, Japan ]
  • Takao Suzuki [ Department of Physical Therapy, Aomori University of Health and Welfare, Aomori 030-8505, Japan ]
  • Sang-Kil Lee [ Cardiovascular & Metabolic Disease Center, College of Biomedical Science & Engineering, Inje University, Gimhae 621-749, Korea ]
  • Taeyoung Kang [ College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea ]
  • Yonggeun Hong [ 2Deaprtment of Rehabilitation Science in Interdisciplinary PhD Program, Graduate School of Inje University, Gimhae 621-749, Korea/Cardiovascular & Metabolic Disease Center, College of Biomedical Science & Engineering, Inje University, Gimhae 621-749, Korea ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    Reproductive & developmental biology
  • 간기
    계간
  • pISSN
    1738-2432
  • eISSN
    2288-0151
  • 수록기간
    1977~2018
  • 십진분류
    KDC 527 DDC 636

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