Synthesis and characterization of nanocrystalline trivalent silver polydiguanide complex was described. The antibacterial activity of the synthesized nanoparticles was evaluated against burn wound pathogens. Synthesis of essentially monodispersed nanoparticles of higher valent metal complex was accomplished by oxidation of the monovalent silver, followed by stabilization of the oxidized higher-valent metal through complexation with chlorhexidine, a polydiguanide ligand in a reverse microemulsion at room temperature. Their antibacterial potencies were assessed invitroby determining the MICs and MBCs against four Gram-positive and four Gram-negative bacteria using agar dilution and microdilution methods. The synthesized nanoparticles showed strong antibacterial activity against the tested Gram (+)/(-) and methicillinresistant Stahylococcusaureus (MRSA) strains. The minimal inhibitory concentrations (MICs) of the synthesized complex were much lower than those of the ligand, AgNO3, and the gold standard, silver sulfadiazine. These nanoparticles may serve as a new generation antibacterial metallopharmaceutical in wound care.
키워드
Silverpolydiguanideantibacterial
저자
Sukdeb PAL [ College of Pharmacy, Seoul National University, Seoul, 151-742. ]
Joon Myong SONG [ College of Pharmacy, Seoul National University, Seoul, 151-742. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동