Earticle

초록

영어

Vitiligo is an acquired disorder of pigmentation in which depigmentation of skin and hairs occurs due to loss of functional melanocytes from the epidermis. It is known that the existence of inactive melanoblasts in the hair root follicles provide a melanocyte source for repigmentation in
vitiligo. Migration of these melanocyte precursors from the outer root sheath of hair follicles into clinically depigmented epidermis is crucial for repigmentation in vitiligo therapy. An effective treatment has been proposed that would stimulate these inactive melanoblasts to migrate from the hair follicle to the nearby epidermis. Although the current phototherapies may induce varying degrees of repigmentation in vitiligo lesions, treatment challenges persist, as either not all patients respond to available therapies and the treatment duration is too long or sometimes a plateau effect is seen with the treatment becoming less effective after an initial response. Lowpower lasers and light-emitting diodes (LED) are well-accepted therapeutic tools in the treatment of infected, ischemic, and hypoxic wounds, along with other soft tissue injuries. To evaluate the potential of LED on melanoblasts, a Melb-a cell line was subjected to LED irradiation and its effect on differentiation, proliferation and migration of melanoblasts were investigated. The findings of the present study may be important in developing new strategies for vitiligo treatment.

키워드

저자

• Sang-Joo PARK [ Department of Biological Engineering, Inha University, Incheon, Korea ]
• Sumathy BABITHA [ Department of Biological Engineering, Inha University, Incheon, Korea ]
• Hyang-Bok LEE [ Department of Biological Engineering, Inha University, Incheon, Korea ]
• Dung HOANG NGUYEN [ Department of Biological Engineering, Inha University, Incheon, Korea ]
• SunA YOON [ Department of Biological Engineering, Inha University, Incheon, Korea ]
• Jimin UM [ Department of Biological Engineering, Inha University, Incheon, Korea ]
• Jeong-Hyun SHIN [ Department Dermatology, Inha university Hospital, Incheon, Korea. ]
• Eun-Ki KIM [ Department of Biological Engineering, Inha University, Incheon, Korea ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576