Dong Sam KIM, Eun-Jin YANG, Ji-Young MOON, Min-Jin KIM, Chan-Shick KIM, Wook Jae LEE, Nam Ho LEE, Chang-Gu HYUN
언어
영어(ENG)
URL
https://www.earticle.net/Article/A119846
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원문정보
초록
영어
As a herbal medicine, seaweed has been used in traditional cosmetics, in treatments for cough, boils, goiters, stomach ailments, and urinary diseases, and for reducing the incidence of tumors, ulcers, and headaches. Despite the fact that seaweeds are frequently used in the practice of human health, little is known about the role of seaweed in the context of inflammation. This study was aimed to investigate the influence of Jeju endemic seaweed on RAW 264.7 cells under the stimulation of LPS. In this study, ethyl acetate extracts obtained from 14 different kinds of Jeju seaweeds were screened for inhibitory effects on pro-inflammatory mediators. Our results reveal that 5 seaweeds, Laurencia okamurae, Grateloupia elliptica, Sargassum thunbergii, Gloiopeltis furcata, and Hizikia fusiformis, were potent inhibitors of the production of pro-inflammatory mediators such as NO, PGE2, IL-6, and TNF-a. Based on these results, the anti-inflammatory effects of these seaweeds, together with their low cell toxicity, suggest potential therapeutic applications in the regulation of the inflammatory response.
키워드
nitric oxideseaweedsIL-6PGE2
저자
Dong Sam KIM [ Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI), Jeju 699-943, Korea. ]
Eun-Jin YANG [ Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI), Jeju 699-943, Korea. ]
Ji-Young MOON [ Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI), Jeju 699-943, Korea. ]
Min-Jin KIM [ Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI), Jeju 699-943, Korea. ]
Chan-Shick KIM [ Faculty of Biotechnology, Cheju National University, Jeju 690-756, KoreaTech Development Institute (HiDI), Jeju 699-943, Korea. ]
Wook Jae LEE [ Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI), Jeju 699-943, Korea. ]
Nam Ho LEE [ Department of Chemistry, Cheju National University, Jeju 690-756, Korea. ]
Chang-Gu HYUN [ Jeju Biodiversity Research Institute (JBRI), Jeju High-Tech Development Institute (HiDI), Jeju 699-943, Korea. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동