Optimized Extraction and Formulation of Ledebouriella Seseloides Root, Scutellaria B aicalensis Root, and B upleurum Falcatum Root for Improving Atopic Dermatitis
Su Jung KIM, Sang Hyun MO, Chang Il LIM, Ji Yeon SUNG, Ae Jin JUNG, Dai Hyun JUNG
언어
영어(ENG)
URL
https://www.earticle.net/Article/A119845
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
Various natural herbal sources provide a defensive mechanisms against various skin diseases especially allergic skin diseases. Now days, most of them are caused by contaminated environmental pollution and related reactive oxygen species. Based on DPPH assay, three oriental herbal sources, Ledebouriella seseloides root, Scutellaria baicalensis root, and Bupleurum falcatum root showed strong anti-oxidant activities among 28 oriental herbal sources. We found that specific ratio among three herbal sources could show more increased anti-oxidant effect and anti-atopic effect with lowered cellular toxicities. We conducted the anti-atopic dermatitis effects on two pathological phenomena. One is expression of defensin peptide and the other is expression of atopic dermatitis-mediated cytokine. On natural human skin, there are defensin peptides with a major role in the barrier function and the innate host immunity against bacteria. These antimicrobial peptides are small, cationic, amphiphilic peptides of around 50 to 70 amino acids with distinct three set of disulfide bonds. So far, isoform 3 (human beta-defensin 3, hBD-3) is suggested as key defensin in human keratinocyte. The specifically formulated herbal extract showed an increase of hBD3 and decrease of atopic dermatitis-mediated cytokine.
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동