Significant improvements have been reported in development of biomaterials to engineer stem cell therapeutics. Despite these advances in biomaterial development for stem cell engineering, the diversity of functional materials still remains limited, in part due to their slow, multistep syntheses, and complicated modifications. The customization of each synthetic reaction and multiple steps limits the ability to generate a significant library size with diversity. To overcome these limitations, we have established combinatorial biomaterial libraries with chemical approaches which allow the simple, rapid, and parallel generation of materials and screened biomaterials optimal for stem cell engineering. Compared with commercially available reagents, some of identified materials have shown higher efficiency of delivering DNA, mRNA or siRNA for genetic modification of stem cells. These genetically engineered stem cells have exhibited enhanced therapeutic efficacy of treating cardiovascular or bone diseases. Interestingly, some of screened biomaterials could support clonal growth or specific differentiation of pluripotent stem cells. The high-throughput screening technology reported here could provide efficient tools for developing stem cell therapeutics for various types of destructive diseases.
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동