Nanobiocatalysis and Its Potential Applications Symposium : Co-organized by Converging Research Center for Biomolecular Process Engineering, Korea Biotech R&D Group - Chairs : Byung-Gee KIM (Seoul National University) and Jungbae KIM (Korea University)
Self-Assembled N anostructured M aterials and Applications to Biocatalysis and Biosensors
Self-assembled nanostructured materials have attracted much attention owing to their application to catalyst supports, hosts for biomolcules, and sensors. The first synthesis of ordered mesoporous material stimulated research on the self-assembly of block copolymers with inorganic materials. Herein, we present functional nanostructured materials synthesized by the self-assembly of block copolymers with inorganic materials. Highly crystalline mesoporous transition metal oxides were fabricated through ‘one-pot’ assembly method employing PI-b-PEO block copolymers. We developed intermetallic nanoparticle loaded highly ordered mesoporous carbon and transition metal oxides by the assembly of PI-b-PEO block copolymer. We have developed multifunctional nano-biocatalyst using various designed nanostrucutred materials. Hierarchically ordered mesocellular mesoporous silica materials (HMMS) were synthesized using a single structure-directing agent. To improve the retention of enzymes in HMMS, we adsorbed enzymes, and then employed crosslinking using glutaraldehyde (GA). The resulting crosslinked enzyme aggregates (CLEAs) show an impressive stability with extremely high enzyme loadings. Magnetically separable and highly active enzyme system was developed using nanostrucutred magnetic materials. Magnetically switchable bioelectrocatalytic system was constructed using magnetic mesocellular carbon foam (Mag-MCF-C) with ultra-large mesopores. Large cellular porous silica materials were synthesized by the self-assembly of commercially available block copolymers, P123. One-pot multi-catalyst system, so called "nanofactory", was developed entrapping magnetic nanoparticles and oxidases in large cellular mesoporous silica with high loadings of simultaneously above 40 wt% MNPs and 20 wt% enzymes. Our approach provided highly loaded MNP system and any highly loaded enzymes with superior activity, stability, and reusability, thereby making further applications as versatile sensors for detecting DNA, protein, and cell highly promising.
저자
Jinwoo Lee [ Department of Chemical Engineering/School of Environmental Science and Engineering, POSTECH ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동