Earticle

초록

영어

Relatively large amounts of GABA can be produced by the fermentation of rice bran. Therefore, this study was conducted to investigate the effects of GABA on the secretion of melatonin and serotonin for the development of a sleep inductive compound. The secretion levels of melatonin and serotonin from mice were found to be 3.425±0.182 pg/mL and 5.37±0.963 ng/mL, respectively, in response to feeding 120 mg/mL of GABA while they were 2.607±0.41 pg/mL in the control. The secretion of both melatonin and serotonin was increased up to the 13.51% and 34.99%, respectively, when compared to the negative control. However, the feeding of milk alone did not have a great effect on the melatonin and serotonin secretions. Conversely, feeding of milk with GABA enhanced the secretion of serotonin. The amounts of both melatonin and serotonin secreted increased with respect to the increase in GABA concentrations during feeding. Interestingly, the induction level of melatonin was relatively higher than that of serotonin in response to feeding 120 mg/ mL of GABA. This is the first study to report that GABA has an ability to induce sleep related hormones in mice; therefore, it has the potential for use as a natural sleep aid.

목차

Abstract
 서론
 재료 및 방법
  실험동물
  사육환경
  GABA의 제조
  GABA와 약물투여
  혈액채취
  시약
  Melatonin 정량
  Serotonin 정량
  통계
 결과 및 고찰
  Melatonin 정량
  Serotonin 정량
 요약
 문헌

키워드

저자

• 김승섭 [ Seung-Seop Kim | 강원대학교 BT특성화학부대학 생물소재공학과 ]
• 오성호 [ Sung-Ho Oh | 강원대학교 BT특성화학부대학 생물소재공학과 ]
• 정명훈 [ Myoung-Hoon Jeong | 강원대학교 BT특성화학부대학 생물소재공학과 ]
• 조석철 [ Seok-Cheol Cho1 | 경희대학교 피부생명공학센터 ]
• 국무창 [ Moo-Chang Kook | 경희대학교 피부생명공학센터 ]
• 이석호 [ Seok-Ho Lee | 바이오벤 ]
• 변유량 [ Yu-Ryang Pyun | 바이오벤 ]
• 이현용 [ Hyeon-Yong Lee | 강원대학교 BT특성화학부대학 생물소재공학과 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국식품과학회지 [Korean Journal of Food Science and Technology]

• 간기

  격월간

• pISSN

  0367-6293

• 수록기간

  1969~2011

• 십진분류

  KDC 574 DDC 664