Earticle

초록

영어

The in vivo and in vitro effects of oriental herb extracts of Cassia obtusifolia, Taraxacum platycarpum and Ulmusmacrocarpa on anti-atopic allergic reaction were evaluated in this study. A mixture of these extracts exhibited more potent anti-allergic activities in human mast cells than those from individual extracts. The herbal mixture significantly inhibited the release of compound 48/80-induced β-hexosaminidase release in the human mast cell line, HMC-1. The mixture also suppressed the production of PMA and A23187-induced inflammatory cytokines in HMC-1 cells. To further investigate the in vivo effects of the herbal mixture, a Dermatophagoides farinae (DF)-induced atopic dermatitis mouse model was utilized. Oral administration of the herbal mixture significantly decreased the ear thickness and swelling in DF treated NC/Nga mice in a dose dependent manner. Furthermore, serum levels of IgE and interleukin-4 (IL-4) were significantly decreased, whereas interferon-gamma (IFN-γ) levels were increased in the mixture administrated groups when compared to the control. Taken together, our data indicate the possibility of using a mixture of the oriental herb extract to relieve symptoms of atopic dermatitis.

목차

서론
 재료 및 방법
  재료 및 시약
  시료의 제조
  세포배양 및 β-hexosaminidase 측정
  Cytokine의 분비 억제 효과 측정
  실험동물
  NC/Nga 마우스 피부염 유도 및 생약재 추출혼합물 투여
  NC/Nga 마우스 혈중 IgE와 cytokine 분석 및 조직학적 관찰
  통계분석
 결과 및 고찰
  HMC-1에서의 탈 과립 억제 효과
  HMC-1에서의 cytokines 분비 억제 효과
  생약재 복합추출물이 NC/Nga 마우스 귀의 부종에 미치는 효과
  생약재 복합 추출물이 NC/Nga 마우스의 혈청 IgE 및 cytokine분비에 미치는 영향
 요약
 감사의 글
 문헌

키워드

저자

• 양희진 [ Hee-Jin Yang | 성균관대학교 식품생명공학과 ]
• 박계원 [ Kye Won Park | 성균관대학교 식품생명공학과 ]
• 김현석 [ Hyun-Suck Kim | (주)성균바이오텍 ]
• 조수묵 [ Soo-Muk Cho | 국립농업과학원 기능성식품과 ]
• 박기문 [ Ki-Moon Park | 성균관대학교 식품생명공학과 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국식품과학회지 [Korean Journal of Food Science and Technology]

• 간기

  격월간

• pISSN

  0367-6293

• 수록기간

  1969~2011

• 십진분류

  KDC 574 DDC 664