pH-Responsive hydrogels based on the methacrylic acid(MAA) are widely used for biomaterial and pharmaceutical fields because of their unique swelling properties in response to the external pH changes. In order to develop a smart delivery system for cosmetic active ingredients such as arbutin and ascorbic acid, pH-responsive P(MAA-co-EGMA) hydrogels were synthesized via dispersion photopolymerization and used as a carrier. The hydrogel microparticles showed a pH-responsive behavior, at low pH a small amount of cosmetic active ingredients was released while at high pH a relatively large amount of cosmetic active ingredients was released from the hydrogels. To determine the protective ability of the P(MAA-co-EGMA) hydrogel microparticles for ascorbic acid, ascorbic acid and ascorbic acid-loaded microparticles were treated with high temperature. As a result, the hydrogel microparticles were able to protect the loaded ascorbic acid. These results indicate that the P(MAA-co-EGMA) hydrogel microparticles can be used as smart delivery carriers for cosmetic active ingredients with which the release of cosmetic active ingredients from the hydrogels can be controlled by the external pH changes.
키워드
pH-sensitive hydrogelsmart delivery systemcosmetic active ingredients
저자
Eunmi LEE [ Dept. of Chemical Engineering, Hongik University ]
Kyu sik KIM [ Nabion Co. Ltd ]
Bumsang KIM [ Dept. of Chemical Engineering, Hongik University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
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