Earticle

초록

영어

Atherosclerosis is a disease where vulnerable plaques build up on the inside of arteries leading to serious problems including heart attack, stroke, or even death. Current computed tomography (CT) is one of the methods to detect the atherosclerotic plaques but the CT contrast
agents like iodine-based compounds have several limitations such as short imaging times due to rapid renal clearance, renal toxicity, and vascular permeation. In this study, in order to overcome current CT contrast agent limitations, we have developed liposomal contrast
agents that could be taken easily by the macrophages which are abundant in the atherosclerotic plaques. The method to synthesize the liposomal contrast agents containing iodine compounds was established and the effect of cholesterol (CHOL) on the contrast effect and stability of the liposomal contrast agents was investigated. There was no significant contrast difference according to the CHOL concentrations. However, as the CHOL concentration was higher than 10%, the particle size of the liposomal contrast agents increased abruptly, which
was inappropriate for the use of contrast agents. In conclusion, 8.5% of CHOL concentration was the best content for the liposomal contrast agent in respect to the particle size and stability of the liposomal contrast agents.

키워드

저자

• Hanjin SHIN [ Dept.of Chemical Engineering, Hongik University ]
• Namhee PARK [ Dept.of Radiology & Research Institute of Radiological science Yonsi, Seoul 120-749, Korea. ]
• Byoungwook CHOI [ Dept.of Radiology & Research Institute of Radiological science Yonsi, Seoul 120-749, Korea. ]
• Bumsang KIM [ Dept.of Chemical Engineering, Hongik University ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576