Photodynamic therapy (PDT) is a promising method for the treatment of several diseases including cancer. It involves the systemic administration of photosensitizers(PSs) such as porphyrin, followed by local photoirradiation with the light of a specific wavelength.[1] In this work, a 3rd generation dendrimer porphyrin (DP Mw ~8,000 g/mol) with 32 carboxyl groups on the periphery was used as a component to prepare a layer-by-layer (LbL) structure via an electrostatic adsorption using its anionic peripheral groups.[2] To enhance the efficacy and tumor-specificity of PDT, poly(allylamine hydro chloride) (PAH, Mw ~50,000 g/mol) / DP nanocarrier was constructed through a LbL self-assembly of PAH and DP on a removable template. It has been reported that the optimal size of drug carriers for efficient delivery of an antitumor agent to a tumor is round 100-200 nm. We chose the monodispersed polystyrene nanoparticles with a diameter of 100 nm which can be dissolved in chloroform.[3] The anticancer drug could be encapsulated into the nanocarriers and its release from hollow polyelectrolyte nanocarriers can be controlled by changes of membrane permeability, which respond to stimulus such as pH.
키워드
layer-by-layerdendrimer porphyrindrug delivery system
저자
Kyung Jin SON [ Dept. of chemical and biomolecular engineering, Yonsei Univ., Seoul. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
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