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Efficency of herbal extracts capable of inducing skin stem cell differentiation, and migration as a treatment regime for Vitiligo

첫 페이지 보기
  • 발행기관
    한국생물공학회 바로가기
  • 간행물
    한국생물공학회 학술대회 바로가기
  • 통권
    2009 추계학술대회 및 국제심포지움 (2009.11)바로가기
  • 페이지
    pp.247-247
  • 저자
    Babitha SUMATHY, Sang-Joo PARK, Dung Hoang NGUYEN, Yu Ri LEE, SunA YOON, Jimin UM, Jeong-Hyun SHIN, Eun-Ki KIM
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A115313

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원문정보

초록

영어
Vitiligo is one of the most psychologically devastating skin diseases. characterized by areas of
depigmented skin resulting from loss of epidermal melanocytes. The prevalence of this disease varies from 0.1% to 2% in various global populations. It is known that the existance of inactive melanoblasts in hair root follicles provide a melanocyte source for repigmentation in Vitiligo. Differentiation and migration of these melanocytes precursors from the outer root sheath of hair follicles into clinically depigmented epidermis is crucial for the repigmentation in Vitiligo therapy. An effective treatment regime has been proposed that would stimulate the inactive melanoblasts in the hair follicle to divide, proliferate and migrate upward along the surface of outer root sheath to the nearby epidermis. Melanoblasts are defined as unpigmented but committed precursors of melanocytes. The characteristic phenotype of melanoblasts includes a lack of expression of tyrosinase and no DOPA staining or melanin production, Thus, those cells provide an ideal model for studing the effect of natural herbs on differentiation of unpigmented melanoblasts to pigmented melanocytes, and to characterize the mechanisms involved.To evaluate the potential of herbal candidates in treatment of Vitiligo, we studied its effects on the differentiation, proliferation and migration of melanoblast cells. Crude herbal extract was added to the complete RPMI medium, and its effect on differentiation, proliferation and migration of melanoblasts were investigated. Selected herbal candidates induced 67% to 70% melanin induction and differentiation. Transwell migration assay showed the potential of these candidates to induce direct migration of treated cells. The findings of present study are significant in the direction of
developing safer strategies for Vitiligo treatment.

키워드

Vitiligo repigmentation melanoblasts migration

저자

  • Babitha SUMATHY [ Department of Biological Engineering, Inha University, Incheon 402-751. ]
  • Sang-Joo PARK [ Department of Biological Engineering, Inha University, Incheon 402-751. ]
  • Dung Hoang NGUYEN [ Department of Biological Engineering, Inha University, Incheon 402-751. ]
  • Yu Ri LEE [ Department of Biological Engineering, Inha University, Incheon 402-751. ]
  • SunA YOON [ Department of Biological Engineering, Inha University, Incheon 402-751. ]
  • Jimin UM [ Department of Biological Engineering, Inha University, Incheon 402-751. ]
  • Jeong-Hyun SHIN [ Department of Dermatology, Inha University School of Medicine, Incheon 400-711. ]
  • Eun-Ki KIM [ Department of Biological Engineering, Inha University, Incheon 402-751. ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
  • 설립연도
    1984
  • 분야
    공학>생물공학
  • 소개
    이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다 1. 생물공학 분야의 발전을 위한 연구 협력 2. 생물공학의 실용화를 촉진시키기 위한 산학 협동 3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최 4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간 5. 생물공학 발전을 위한 정책 건의 6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동

간행물

  • 간행물명
    한국생물공학회 학술대회
  • 간기
    반년간
  • 수록기간
    1985~2013
  • 십진분류
    KDC 476 DDC 576

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