Earticle

초록

영어

Antimicrobial peptides (AMPs) play an important role to cope with invasion of microorganisms. Based on the antimicrobial mechanism of AMPs, there have been considerable efforts to improve the antimicrobial activities of a-helical AMPs in association with structure-activity relationship (SAR) study. In this study, to demonstrate the relationship of distribution of cationic amino acids and antimicrobial activity of AMP, we designed pertinent KL (lysine and leucine) model AMPs to
have same hydrophobic arc, net charge, and overall hydrophobicity and investigated effect of cationic amino acid distribution. Next, we confirmed it using natural AMP analogue, CRAMP18, and its derivatives. In results, we observed enhancement of AMP activity by modulation of dispersity for cationic distribution. Thus, we proposed that distribution of cationic amino acids on the hydrophilic surface of helical wheel structure is a determining factor for antimicrobial
activity of AMP. It is expected that antimicrobial activities of natural AMPs can be improved by rational redesign of amino acid sequences through rearrangement of positively-charged amino acids on the hydrophilic surface region of helical wheel to have more uniform dispersity as well as parallel regulations of other known structural parameters.

키워드

저자

• Im Gyu KIM [ Depart. of chemical Engineering, Pohang University of Science and Technology ]
• Young Soo KIM [ Depart. of chemical Engineering, Pohang University of Science and Technology ]
• Hyung Joon CHA [ Depart. of chemical Engineering, Pohang University of Science and Technology ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576