Earticle

초록

영어

Newcastle disease virus (NDV) V protein is well known for its interferon antagonistic activity (1-4). The addition of anti-interferon antibody for blocking the binding between interferons secreted from NDV-infected cells and interferon receptors increases NDV virus productivity in cell-based production system. To block the host cellular interferon signaling efficiently, the stable cell lines expressing either lentogenic or velogenic NDV V protein were established. The overexpression of either lentogenic or velogenic V protein has an effect on enhancing NDV production kinetics but no effect on Japanese encephalitis virus (JEV) production. The overexpression of
NDV V protein functions as an interferon antagonist through inhibiting NDV-induced increase of type-I interferons rather than incorporating virus particles as a structural protein or degrading STAT proteins (5-9). And the interferon signals in NDV V-expressing cell lines were weakened by decreased activation or expression of dsRNAactivated enzymes, PKR and OAS. These interferon antagonist activities can help rapid virus replication and spread in the early phase
of virus production.

키워드

저자

• Juno JANG [ Dept. of Biotechnology, School of Life Sciences and Biotechnology, Korea University ]
• Sung-Hwan HONG [ Dept. of Biotechnology, School of Life Sciences and Biotechnology, Korea University ]
• Ik-Hwan KIM [ Dept. of Biotechnology, School of Life Sciences and Biotechnology, Korea University ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576