Currently, obesity has become the risk factor to lead many metabolic diseases including hypertension, type 2 diabetes mellitus, cancer and osteoarthritis. Capsaicin as a potential thermogenic agent has been reported as a tool for obesity management by increasing energy expenditure and fatty acid oxidation on skeletal muscle. In the present study, effects of capsaicin on expression of skeletal muscle proteins in rats fed with high-fat diet (HFD) were investigated. Rats were fed with the HFD for a period of 8 week and/or were treated with capsaicin. After HFD feeding, capsaicin-treated group weighed an average of 8% less than HF-diet group. Capsaicin treatment increased phosphorylation of AMPK and ACC compared with HFD control group. HFD fed rats led to increase of UCP3 protein expression, whereas capsaicin treatment reduced UCP3 contents. These data suggest that effect of capsaicin on energy expenditure and fatty acid oxidation in muscle might be mediated through activating AMPK-ACC-malonyl-CoA metabolic signaling pathway. The proteomic analysis demonstrated that 33 spots were differentially significantly expressed from a total of about 500 matched spots, of which 27 spots were identified as muscle proteins altered in response to capsaicin feeding, and 6 spots were found to be unidentified by mass fingerprinting.
키워드
capsaicinobesityskeletal muscle
저자
Dong Hyun KIM [ Department of Biotechnology, Daegu University ]
Jong Won YUN [ Department of Biotechnology, Daegu University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동