Earticle

초록

영어

Alopecia is not life threatening, but patients who undergo alopecia often experience severe mental stress. In addition, the number of individuals afflicted by alopecia has been increasing steadily. The most effective treatment of alopecia developed to date is auto hair transplantation. To overcome the limitations associated with current therapies for the treatment of alopecia, many researchers have attempted to revive hair follicles by in vitro culture of hair follicle cells and subsequent implantation in the treatment area. Previously, we demonstrated that umbilical cord-derived mesenchymal stem cells (UC-MSCs) could be isolated and expanded successfully
from the Wharton's Jelly. Culture-expanded UC-MSCs formed aggregate similar to native dermal papilla (DP) in special media (DPFM), and reconstructed dermal papilla like tissues (DPLTs) could induce new hair follicles. The purpose of the present study was to optimize the reconstruction of DPLTs. As in the case of MSCs, when compared to differentiated cells, DPLTs require an additional step to induce differentiation into dermal papilla cells. However, it is necessary to use hepatocyte growth factor (HGF) in the differentiation step, which is relatively expensive. To reduce the expenses associated with cell therapy using MSCs, it is necessary to
optimize this differentiation step. To accomplish this, we evaluated the effects of various cells inoculation densities and growth factors during differentiation.

키워드

저자

• Bo-Young YOO [ Dept. Biochemical and Chemical Engineering, Dongguk University. ]
• Hee-Hoon YOON [ Dongguk University Research Institute of Biotechnology. ]
• Kye-Yong SONG [ Dept. Pathology, College of Medicine, Chung-ang University. ]
• Jung-Keug PARK [ Dept. of Medical Biotechnology, Dongguk University. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576