Inonotus obliquus has been known to cinder conk and fungus in the family Hymenochaetaceae. Inonotus obliquus has been traditionally used for both medicinal and food purpose. Fruiting body hot-water extract of Inonotus obliquus (IFHWE), especially beta-glucan constituent, has been associated with anti-tumor and immunomodulatory activity. Macrophages are phagocytic acting in innate immunity and cellmediated immunity. Phagocytosis is involved in the acquisition of nutrients for some cells, which is the major mechanism used to remove cell debris and pathogens in the immune system. Inonotus obliquus has been known to be related with macrophage-mediated innate immune responses. Activated macrophages such as the phagocytic uptake and release of toxic molecules including nitric oxide (NO) and reactive oxygen species (ROS) were investigated. At the last, direct cytotoxicity of IFHWE was evaluated to examine the anti-tumor effect on HeLa cells and B16-F10 cells. The purpose of this study was to investigate the immunomodulatory activity of hot-water extracts from Inonotus obliquus in RAW 264.7 cell line.
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
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