You Ah KIM, Jung Im LEE, Chang-Suk KONG, Jinhyeok LEE, Haejin KIM, Youngwan SEO
언어
영어(ENG)
URL
https://www.earticle.net/Article/A115142
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원문정보
초록
영어
In search for novel bioactive secondary metabolites from salt marsh plants, a number of halophytes were collected in western coastal area of Korea and screened for a series of biological activities. Among the collected halophytes, Whole plants of Vitex rotundifolia were extracted for 2 day with dichloromethane and methanol, respectively. The combined crude extracts were concentrated in vacuo and then fractionated into n-hexane, 85% aq. MeOH, n-BuOH, and water fractions. The antiproliferative effects of the crude extracts and their solvent fractions against HT1080, AGS and HT-29 human cancer cells were compared with the control at the concentrations of 10, 50, and 100 μg/mL by using MTT assay. In the comparative analysis, the 85% aq. MeOH fraction exhibited the strongest antiproliferative effects on human cancer cell lines in a dose-dependent manner (p < 0.05). The growth inhibition rate on HT1080, AGS, HT-29 human cancer cells was 74.0%, 79.9%, and 31.6%, respectively, when the 85% aq. MeOH fraction (10 μg/mL) was added to them. These results suggested that active compounds having a strong anticancer effect can be isolated from Vitex rotundifolia
키워드
Vitex rotundifoliaanticancersalt marsh plants
저자
You Ah KIM [ Division of Marine Environment & Bioscience, Korea Maritime University ]
Jung Im LEE [ Division of Marine Environment & Bioscience, Korea Maritime University ]
Chang-Suk KONG [ Marine Bioprocess Research Center, Pukyong National University ]
Jinhyeok LEE [ Division of Marine Environment & Bioscience, Korea Maritime University ]
Haejin KIM [ Division of Marine Environment & Bioscience, Korea Maritime University ]
Youngwan SEO [ Division of Marine Environment & Bioscience, Korea Maritime University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동