Jongho YI, Jeong Wook LEE, Sol CHOI, Ji Mahn KIM, Sang Yup LEE
언어
영어(ENG)
URL
https://www.earticle.net/Article/A115130
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원문정보
초록
영어
Mannheimia succiniciproducens MBEL55E, a gram-negative facultative capnophilic rumen bacterium, produces mainly succinic acid by metabolizing a wide range of carbon sources including pentose sugar (xylose), hexose sugars (fructose and glucose), and disaccharides (lactose, maltose, and sucrose). Fermentation studies have shown that M. succiniciproducens prefers sucrose to other carbon sources and produces equal or higher titers of succinic acid on this sugar. Hence, we identified genes involved in the sucrose transport and utilization. The sucrose-utilizing phenotype was examined both for the parent strain and the deletion mutant of each gene. The corresponding enzymes were further characterized by measuring enzyme activities using radio-labeled substrate. As a consequence, several unique features on sucrose uptake and utilization system were found in Mannheimia. Strategies evolved from this characterization of the sugar metabolism will also be suggested in detail. [This work was supported by the Genome-Based Integrated Bioprocess Development Project of the Ministry of Education, Science and Technology (MEST). Further supports by the LG Chem Chair Professorship, Microsoft, IBM SUR, WCU (World Class University) program through the National Research Foundation of Korea funded by MEST (R32-2008-000-10142-0) are appreciated.]
Jongho YI [ Metabolic and Biomolecular Engineering Laboratory, Department of Chemical and Biomolecular Engineering (BK21 program), KAIST ]
Jeong Wook LEE [ Metabolic and Biomolecular Engineering Laboratory, Department of Chemical and Biomolecular Engineering (BK21 program), KAIST ]
Sol CHOI [ Metabolic and Biomolecular Engineering Laboratory, Department of Chemical and Biomolecular Engineering (BK21 program), KAIST ]
Ji Mahn KIM [ Metabolic and Biomolecular Engineering Laboratory, Department of Chemical and Biomolecular Engineering (BK21 program), KAIST ]
Sang Yup LEE [ Metabolic and Biomolecular Engineering Laboratory, Department of Chemical and Biomolecular Engineering (BK21 program), and Department of Bio and Brain and Bioinformatics Research Center, KAIST ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동