Earticle

초록

영어

Lactide, diolide of lactic acid, as a monomer for ring-opening polymerization of PLA (poly lactic acid) is key compound for industrial production of PLA. PLA is one of biodegradable plastics from nature material.[1] Because physical property of PLA is affected by ratio of enantiomer, synthesis of enantioseletive lactide is needed to produce PLA with high physical property.[2] However, enantioseletive synthesis from lactate to lactide using lipase has not been reported until now. In our study, commercial CALB called Novozym 435 was found to be able to synthesize lactide from lactate and showed R-specific enantioselectivity. As reaction temperature was changed from 5℃ and 60℃, the rate of consumption and conversion is
gradually increased, but rate of conversion was decreased over time in fixed temperature. When lactide was used as a substrate in reaction system, it was found that lactide was reduced about 40%. In this result, CALB can not only convert from lactate to lactide but also break ring conformation of lactide.[3] Actually, when water activity of enzyme was controlled, lactide was reduced drastically at high water activity.[4] This result demonstrates that water activity influences both formation and reduction of lactide and concern with water content of enzyme.

키워드

저자

• Byoung Wook JEON [ Dept. of Chemical Engineering, Kwangwoon Universitiy, Seoul, 139-701. ]
• Hyun Sook KIM [ Dept. of Chemical Engineering, Kwangwoon Universitiy, Seoul, 139-701. ]
• Dae Haeng CHO [ Dept. of Chemical Engineering, Kwangwoon Universitiy, Seoul, 139-701. ]
• Hyeok LEE [ Bioorganic Science Division, Korea Research Institute of Chmical Technology ]
• Yong Hwan KIM [ Dept. of Chemical Engineering, Kwangwoon University ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576