Earticle

초록

영어

Prenylated flavonoids and dihydroxynapthalenes are natural products that exhibit diverse biological effects and often represent the active components of various medicinal plants. Aromatic prenyltransferases catalyze the transfer of prenyl moieties to aromatic acceptor molecules and give rise to an astounding diversity of primary and secondary metabolites in plants, fungi and bacteria. We recently amplified, cloned and expressed the aromatic prenyltransferase sp8959 from Streptomyces peucetius ATCC 27952 in E. coli to validate their
functions in vivo. A novel prenyltransferase sp8959 gene is located upstream of THNS gene cluster (type III PKS).This study demonstrated the production of prenylated flavonoids and dihydroxynaphthalenes by biotransformation without feeding of prenyl donors. This method
provides the possibility of generating prenylated flavonoids and dihydroxynapthalenes that occur rarely in nature.

키워드

저자

• Dinesh KOJU [ Institute of Biomolecule Reconstruction, Department of Pharmaceutical Engineering, Sun Moon. ]
• Gopal PRASAD GHIMIRE [ Institute of Biomolecule Reconstruction, Department of Pharmaceutical Engineering, Sun Moon. ]
• Hei Chan LEE [ Institute of Biomolecule Reconstruction, Department of Pharmaceutical Engineering, Sun Moon. ]
• Jae Kyung SOHNG [ Institute of Biomolecule Reconstruction, Department of Pharmaceutical Engineering, Sun Moon. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576