Thai-Hoang LE, Eun-Suk LIM, Yang-Hoon KIM, Jiho MIN
언어
영어(ENG)
URL
https://www.earticle.net/Article/A114524
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원문정보
초록
영어
In this study, we investigated toxic effects of two pharmaceuticals (i.e., verapamil, tramadol) and two commonly used pesticides (i.e., glyphosate, methidathion) on physiological responses such as viability, growth, and reproduction as well as molecular responses such as gene and protein expression in water flea, Daphnia magna. The expression of Arnt, Vtg, CYP4, CYP314 and Dhb was analyzed as representative biomarkers after exposing D. magna to hazardous materials. Our results showed that the expression of these genes in D. magna were significantly down-regulated in response to pesticides. Among five investigated genes, Cyp4 and Cyp314 genes, expressed differently in exposure of glyphosate and methidathion, respectively. This indicated that these two genes could be considered as potential biomarkers. However, in case of pharmaceuticals, although they did not give high affects on gene expression in D. magna, the chronic toxicity tests indicated that both verapamil and tramadol are harmful to the tested organism with respect to reproduction and growth rate. The results suggest that these pharmaceuticals and pesticides have distinguishable toxic modes between them. While the pesticides led to molecular damage such as significantly reduced of five genes, the pharmaceuticals led to a chronic toxicity, not the effect of gene expression caused by acute exposure.
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동