A nanoparticle is a small particle with at least one dimension less than 100 nm. Recently, nanoparticle research attracts public attention due to its potential to be applied to biomedical, optical, and electronic fields. Many scientist and engineer make efforts to develop new nanomaterials to be effective on illness and disease like cancer beyond current imagination. Polymer-based nanoparticles are designed to improve the property of drugs in terms of pharmacokinetics which determines the strength of drug delivery system. We have recently found that orally administered nano-size polystyrene beads pass through the pharynx and are taken up into the intestine. When we fed animals with 50, 100, 200, and 500 nm polystyrene beads, only 50 and 100 nm particles were mobilized beyond the gut and were found to accumulate in the gonad and epidermis. To explore the requirements for nanoparticle transport, we tested uptake of 50 nm particles in worms defective for genes involved in apical transport or endocytosis in intestinal lumen and found which proteins enable nanoparticles to move from the intestine to other sites in the animals. These findings suggest that the upper limit in this size of nanoparticles that can undergo endocytic transport from the lumen to gut and from gut to other organs may be less than 200 nm.
키워드
nanoparticleC.elegansendocytosis
저자
Shin Sik CHOI [ Department of Food and Nutrition, Myongji University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동