Jong Bae Seo, Sung Sik Choe, Seung-Hyung Kim, Eun Mi Jun, Eun Wook Choi, Jae Young Park, Jong Soon Lim, Tae Gyu Lee
언어
영어(ENG)
URL
https://www.earticle.net/Article/A114487
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
Asthma is one of the major public health problems worldwide and the morbidity and mortality of asthma has increased in the past two decades. To develop the botanical new drug for asthma, we discovered natural product that activated beta2-adrenergic receptor( 2AR) in the reporter assay. It also inhibited nuclear factor (NF)- B activation. Administration of the NDR10113 to ovalbumin (OVA)-induced asthmatic mice improved the airway hyperresponsiveness (AHR). Moreover, NDR10113 exhibited a decrease of serum IgE level and bronchial inflammation. Results from flow cytometric analysis (FACS) showed the absolute number of total cells in the lung-draining mediastinal lymph nodes (MLN) were significantly suppressed by NDR10113 administration, and also that absolute numbers of CD3+ T cells, CD4+ Th cells, and B220+ B cells reduced. Furthermore, the lung tissue of NDR10113 treatment group showed much less eosinophils, bloods, and collagen accumulating compared with that of OVA-induced control group. Taken together, these results suggest NDR10113 might be beneficial for the treatment of asthma.
저자
Jong Bae Seo [ Boram Pharm. R&D Center, Biotechnology Incubating Center, Golden Helix, Seoul National University ]
Sung Sik Choe [ Boram Pharm. R&D Center, Biotechnology Incubating Center, Golden Helix, Seoul National University ]
Seung-Hyung Kim [ Institute of Traditional Medicine and Bioscience, Daejeon University ]
Eun Mi Jun [ Boram Pharm. R&D Center, Biotechnology Incubating Center, Golden Helix, Seoul National University ]
Eun Wook Choi [ Boram Pharm. R&D Center, Biotechnology Incubating Center, Golden Helix, Seoul National University ]
Jae Young Park [ Boram Pharm. R&D Center, Biotechnology Incubating Center, Golden Helix, Seoul National University ]
Jong Soon Lim [ Institute of Traditional Medicine and Bioscience, Daejeon University ]
Tae Gyu Lee [ Boram Pharm. R&D Center, Biotechnology Incubating Center, Golden Helix, Seoul National University ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동