Hyun Ah Kang, Jung-Seob Kim, Jung Sun Yum, Heungrok Park, Han Seung Lee, Ohsuk Kwon
언어
영어(ENG)
URL
https://www.earticle.net/Article/A114480
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
Glycans are important components of many biotherapeutic agents, ranging from natural products to molecules based on rational design to recombinant glycoproteins1,2. The glycan components of these agents determine their biological activity and therapeutic efficacy. There are increasingly strong drivers for the development of improved approaches for production of therapeutics with enhanced efficacy and stability. The ultimate goal of our research project, supported by Korean Ministry of Knowledge Economy, is to develop next generation therapeutics through glycan remodeling based on glycomics analysis3, the systematic elucidation of the structure and function of “glycome (complete sets of glycans)” on bio-pharmaceuticals. The project was initially composed of five subprojects; (1) Subproject I: Development of anti-lymphoma therapeutic antibodies by glycoengineering (Mogam/Greencross), (2) Subproject II: Development of HBV therapeutic vaccines by glycan remodeling (Dobeel/Neurotech), (3) Subproject III: Development of therapeutic enzymes for fabry disease by glycan addition (ISU Abxis), (4) Subproject IV: Development of hyaluron derivatives by glycan modification (LG Life Sciences), and (5) Subproject V: Development of glycoexpression systems for glycan remodeling (KRIBB). The successful achievements of the project will surely upgrade the usage potential of these molecules, providing routes to better-targeted, more bioactive drugs with reduced off-target side effects and expanded applications.
저자
Hyun Ah Kang [ Chung-Ang University, Korea Drug Research Association ]
Jung-Seob Kim [ Mogam Biotechnology Research Institute ]
Jung Sun Yum [ Dobeel Co. ]
Heungrok Park [ ISU Abxis Co. Ltd ]
Han Seung Lee [ LG Life Sciences ]
Ohsuk Kwon [ Korea Research Institute of Bioscience and Biotechnology ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동