Jong Gil Lee, Jung-Deok Kim, Sung-Hyun Kim, Jin-Young Park, Seok Joo Hong, Jong-Man Kim, Yong Kee Min, Kun-Do Kim, Moonkwon Lee, Eun Kyu Lee
언어
영어(ENG)
URL
https://www.earticle.net/Article/A114474
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
Molecular imaging technology is becoming more important in biotechnology research, articularly in the development of new drug compounds. High-content screening (HCS) is a drug screening and discovery technique that utilized high resolution fluorescence imaging of live cells. Protein targets of interest inside the cells are detected using fluorescent tags such as the green fluorescent protein or synthetic fluorescence dyes. As such, HCS can be defined as a ‘cell-based assay’ based on molecular imaging to evaluate the various biological functions of a drug candidate. For a successful development of a HCS system, various expertise such as molecular and cell biology, cellular and fluorescence imaging, automation and robotics, and image analysis software should be systematically integrated. From January of 2004, we have carried out the project of ‘Development of High Content Screening Technology and System’ supported by the Ministry of Knowledge Economy. The project consists of three (3) subprojects: (1) Development of high-resolution HCS system equipped with microoptics and fluidic module, (2) Development of image analysis software and system validation technologies, and (3) Development of HCS biocontents commercialization technology. Now, we have successfully developed a prototype of an HCS system, NEXMAN NH-600S. This system can be used for various applications including but are not limited to: drug candidate screening, toxicology testing, environmental risk assessment, etc. In this presentation, the fundamentals and results of the HCS development activities are discussed.
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동