In this presentation, my recent years' interaction with KSBB colleagues will be briefly summarized. Succeeding to my last year's presentation at KSBB spring meeting about biotechnology of medicinal higher fungi, our new progresses in purification of ganoderic acids (antitumor compound) from Ganoderma lucidum and their bioactivity study will be mentioned. Comparative study on individual ganoderic acids (GAs) production and identification of differentially expressed genes between liquid static and shaking cultures of G. lucidum will be mainly demonstrated. The content of individual GAs was higher in liquid static culture than that in conventional shaking culture and the higher production was related to increased transcription of biosynthetic genes. A total of 147 up-regulated ESTs were identified in hyper-production of GA conditions and this study provided interesting information on possible genes functions related to cell differentiation, GA biosynthesis and its regulation. In addition, enhancement of GAs production and biosynthetic gene expression was achieved by addition of phenobarbital in liquid static cultures of G. lucidum. The demonstrated molecular biochemical engineering approach will be useful to the industrialization of the antitumor compound production process.
저자
Jian-Jiang Zhong [ Microbial Metabolism, Ministry of Education, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China ]
Jun-Wei Xu [ Microbial Metabolism, Ministry of Education, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China ]
Cui-Xia Liang [ Microbial Metabolism, Ministry of Education, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동