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Medical / Pharmaceutical Biotechnology Symposium : 좌장 : 이지원 교수(고려대학교)
Structural Chemoproteomics Based Discovery of Molecular Targeting Anti-Cancer Agents
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- 발행기관
- 한국생물공학회 바로가기
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- 간행물
- 한국생물공학회 학술대회 바로가기
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- 통권
- 2009 추계학술대회 및 국제심포지움 (2009.11)바로가기
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- 페이지
- pp.92-92
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A114457
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
- 영어
- Drug molecules usually bind to target proteins controlling their functions to exert pharmacological
effects. The binding between a drug molecule and a protein is initiated by mutual recognition of their three-dimensional (3D) structures which implicate physicochemical properties. Thus, exploring the structural aspects of the recognition is important for understanding drug action mechanisms. Moreover, it enables us to discover new chemicals that fit the active site and mediate the function of the target protein. Such chemicals become drug candidates if they demonstrate proper pharmacokinetics and pharmacological effects without significant toxicity events. Studies for the recognition consist of determination and analysis of the 3D structures of target proteins with bound ligands, more importantly drug molecules. In detail, most 3D structures of iso-type proteins in a family, if not all, have been collected and/or determined for structural analysis. Complex structures have been compared to identify main structural features such as non-bonding interactions, pocket structures, and conformational changes between the proteins and the chemicals in their binding sites. The purpose of this study is conceptually different from that of the “structural proteomics” although we use the same research tools as it does. The structural proteomics generally identifies molecular functions of proteins through the determination of entire protein structures and the comparison of their functional domains. On the other hand, our approach takes advantage of the 3D aspects of the recognition between proteins and ligands, and applies them to drug discovery, being, therefore, named “structural chemoproteomics”. During last several years, CrystalGenomics has applied this method for
the discovery of various drug candidates. Specifically we focused on proteins in the epigenetics and signal transductions. They include families of histone deactylases (HDACs), histone methyl
transferases (HMTs) and kinases. In this presentation, we would like to introduce the ethodology of structural chemoproteomics based drug discovery and discuss recent results obtained from their applications for the discovery of molecular targeted anticancer drug candidates.
저자
간행물 정보
발행기관
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- 발행기관명
- 한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
- 설립연도
- 1984
- 분야
- 공학>생물공학
- 소개
- 이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다 1. 생물공학 분야의 발전을 위한 연구 협력 2. 생물공학의 실용화를 촉진시키기 위한 산학 협동 3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최 4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간 5. 생물공학 발전을 위한 정책 건의 6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
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- 간행물명
- 한국생물공학회 학술대회
- 간기
- 반년간
- 수록기간
- 1985~2013
- 십진분류
- KDC 476 DDC 576
이 권호 내 다른 논문 / 한국생물공학회 학술대회 2009 추계학술대회 및 국제심포지움
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