Extracts from Rhizopus oryzae KSD-815 of Korean Traditional Nuruk Confer the Potential to Inhibit Hypertension, Platelet Aggregation, and Cancer Metastasis in vitro
Sang-Jin Lee, Hyun-Jin Bae, Jiyeon Ryu, Daeyoung Lee, Gye-Won Kim, Namin Baek, Moosik Kwon, Sungyoul Hong
언어
영어(ENG)
URL
https://www.earticle.net/Article/A114151
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원문정보
초록
영어
Rhizopus oryzae KSD-815 was isolated from nuruk that has been used to make Korean traditional wines. This study was performed to investigate the effect of cultures of R. oryzae KSD-815 on cardiovascular disorders and cancer metastasis. Firstly, these cultures were sequentially fractionationed with n-hexane (TAHe), ethylacetate (TAE), n-butanol (TAB), and H2O (TAW). The TAE inhibited the activity of angiotensin-converting enzyme (ACE) and TAB suppressed platelet aggregation in vitro. TAE and TAB inhibited cell motility of human breast cancer cells. Furthermore, TAW interrupted the formation of neovasculature and tube-like structure, and down-regulated the expression of angiogenic factors, basic fibroblast growth factor (bFGF), tumor necrosis factor-α (TNF-α), and hypoxia-inducible factor-1α (HIF-1α) in breast cancer cells. These results indicated that cultures of R. oryzae KSD-815 display the inhibitory activities on hypertension, platelet aggregation, and metastasis, and suggest that these cultures might be further probed for the purposes as therapeutic agents or dietary supplements.
목차
Abstract Introduction Materials and Methods Results and Discussion References
키워드
Rhizopus oryzae KSD-815Korean traditional nurukanti-hypertensionplatelet aggregationanti-metastatic activity
저자
Sang-Jin Lee [ Department of Genetic Engineering, Sungkyunkwan University, Research Laboratories, Kooksoondang Brewery Co., Ltd. ]
Hyun-Jin Bae [ Department of Genetic Engineering, Sungkyunkwan University ]
Jiyeon Ryu [ Department of Genetic Engineering, Sungkyunkwan University ]
Daeyoung Lee [ Natural Products Chemistry Laboratory, Department of Biotechnology, Kyung Hee University ]
Gye-Won Kim [ Research Laboratories, Kooksoondang Brewery Co., Ltd. ]
Namin Baek [ Natural Products Chemistry Laboratory, Department of Biotechnology, Kyung Hee University ]
Moosik Kwon [ Department of Genetic Engineering, Sungkyunkwan University ]
Sungyoul Hong [ Department of Genetic Engineering, Sungkyunkwan University ]
Corresponding author