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Extracts from Rhizopus oryzae KSD-815 of Korean Traditional Nuruk Confer the Potential to Inhibit Hypertension, Platelet Aggregation, and Cancer Metastasis in vitro

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 SCOPUS 바로가기
  • 통권
    Volume 18 Number 6 (2009.12)바로가기
  • 페이지
    pp.1423-1429
  • 저자
    Sang-Jin Lee, Hyun-Jin Bae, Jiyeon Ryu, Daeyoung Lee, Gye-Won Kim, Namin Baek, Moosik Kwon, Sungyoul Hong
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A114151

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원문정보

초록

영어
Rhizopus oryzae KSD-815 was isolated from nuruk that has been used to make Korean traditional wines. This study was performed to investigate the effect of cultures of R. oryzae KSD-815 on cardiovascular disorders and cancer metastasis. Firstly, these cultures were sequentially fractionationed with n-hexane (TAHe), ethylacetate (TAE), n-butanol (TAB), and H2O (TAW). The TAE inhibited the activity of angiotensin-converting enzyme (ACE) and TAB suppressed platelet aggregation in vitro. TAE and TAB inhibited cell motility of human breast cancer cells. Furthermore, TAW interrupted the formation of neovasculature and tube-like structure, and down-regulated the expression of angiogenic factors, basic fibroblast growth factor (bFGF), tumor necrosis factor-α (TNF-α), and hypoxia-inducible factor-1α (HIF-1α) in breast cancer cells. These results indicated that cultures of R. oryzae KSD-815 display the inhibitory activities on hypertension, platelet aggregation, and metastasis, and suggest that these cultures might be further probed for the purposes as therapeutic agents or dietary supplements.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 References

키워드

Rhizopus oryzae KSD-815 Korean traditional nuruk anti-hypertension platelet aggregation anti-metastatic activity

저자

  • Sang-Jin Lee [ Department of Genetic Engineering, Sungkyunkwan University, Research Laboratories, Kooksoondang Brewery Co., Ltd. ]
  • Hyun-Jin Bae [ Department of Genetic Engineering, Sungkyunkwan University ]
  • Jiyeon Ryu [ Department of Genetic Engineering, Sungkyunkwan University ]
  • Daeyoung Lee [ Natural Products Chemistry Laboratory, Department of Biotechnology, Kyung Hee University ]
  • Gye-Won Kim [ Research Laboratories, Kooksoondang Brewery Co., Ltd. ]
  • Namin Baek [ Natural Products Chemistry Laboratory, Department of Biotechnology, Kyung Hee University ]
  • Moosik Kwon [ Department of Genetic Engineering, Sungkyunkwan University ]
  • Sungyoul Hong [ Department of Genetic Engineering, Sungkyunkwan University ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

이 권호 내 다른 논문 / Food Science and Biotechnology Volume 18 Number 6

    피인용수 : 0(자료제공 : 네이버학술정보)

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