Jae-Young Cha, Hyeong-Soo Kim, Sun-Chul Kang, Young-Su Cho
언어
영어(ENG)
URL
https://www.earticle.net/Article/A114149
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
The suppressive effects of glutathione-enriched Saccharomyces cerevisiae FF-8 strain (FF-8 GY) on alcoholinduced hepatotoxicity have been studied. FF-8 GY (256 mg/L) from the fermentation at a large scale bioreactor was used. Either of 5% FF-8 GY or 5% commercial glutathione-enriched yeast extract (GYE) with or without 30% alcohol was tested with rats for 4 weeks. FF-8 GY and GYE were found to reduce those alcohol-elevated serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) activities. Blood alcohol and acetaldehyde were also decreased by FF-8 GY and GYE. Interestingly, FF-8 GY drastically increased both hepatic alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities in comparison to GYE group, thus FF-8 GY would be more effective in blood alcohol and acetaldehyde reduction. Attenuated lipid droplet accumulation in hepatocytes was observed in both FF-8 GY and GYE when alcohol stimulated the accumulation. Therefore, FF-8 GY may be useful to protect liver from alcohol-induced hepatotoxicity.
목차
Abstract Introduction Materials and Methods Result and Discussion References
Jae-Young Cha [ Technical Research Institute, Daesun Distilling Co., Ltd. ]
Hyeong-Soo Kim [ Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, and Regional Research Center, Inje University ]
Sun-Chul Kang [ Department of Biotechnology, Daegu University ]
Young-Su Cho [ Department of Biotechnology, College of Natural Resources and Life Science, Dong-A University ]
Corresponding author