Anti-inflammatory Activities of Chopi (Zanthoxylum piperitum A.P. DC) Essential Oil: Suppression of the Inducible Nitric Oxide Synthase and Cellular Adhesion
The aim of this study is to elucidate the anti-inflammatory activities of chopi (Zanthoxylum piperitum A.P. DC.) essential oil. Essential oil (EO) of chopi was extracted by steam distillation method, and its major constituents were limonene and geranyl acetate. Chopi-EO decreased approximately 38% of nitrite production, as compared to the lipopolysaccharde (LPS)-induced nitrite production. However, chopi-EO and its components did not quench nitric oxide (NO) chemically in cellfree system, and markedly inhibited approximately 40.4% of inducible nitric oxide synthase (iNOS) mRNA transcription. In addition, the inhibition of E-selectin gene transcription by chopi-EO caused the suppression of cellular adhesion. These results suggest that chopi-EO may exert potential anti-immunological inflammatory activity.
목차
Abstract Introduction Materials and Methods Results and Discussion References
Je-Hyuk Lee [ Plant Resource Research Institute, Duksung Women’s University ]
Kyung-Mi Chang [ Plant Resource Research Institute, Duksung Women’s University ]
Gun-Hee Kim [ Plant Resource Research Institute, Duksung Women’s University, Department of Food and Nutrition, Duksung Women’s University ]
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