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Immunomodulatory Effects of a Methanol Extract from Opuntia ficus indica on Murine Splenocytes

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 SCOPUS 바로가기
  • 통권
    Volume 18 Number 6 (2009.12)바로가기
  • 페이지
    pp.1316-1321
  • 저자
    Ginnae Ahn, Jin Hee Kim, Eunjin Park, Yoon Kyu Lim, You-Jin Jeon, Youngheun Jee
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A114135

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원문정보

초록

영어
Multiple beneficial properties of Opuntia ficus indica (OPF) are well established. In the present study, we have investigated the immunological role of OPF extract (OPFE) on murine plenocytes. OPFE dose- and time-dependently enhanced the proliferation of splenocytes without cytotoxicity. Our results also showed that the number of CD4+ helper T cells and CD45R/B220+ pan B cells increased markedly, but not CD8+ cytotoxic T cells or CD11b+ granulocytes/macrophages. In addition, OPFE significantly decreased the production levels of T helper (Th) 1 type cytokines, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α, although had no significantly differences in those of interleukin (IL)-4, a Th2 type cytokine in concanavalin A (Con A)-stimulated blastogenic cells. Furthermore, OPFE alone strongly increased IL-4 roduction and decreased TNF-α production even in the absence of Con A. On the basis of these results, this study suggests that OPFE enhances immunity by regulating the pro- and anti-inflammatory response, indicating that this extract exerts a marked immunomodulatory effect, confirming its usefulness as therapy for immune-related diseases.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 References

키워드

Opuntia ficus indica splenocyte Th1 cytokine Th2 cytokine immunomodulatory effect

저자

  • Ginnae Ahn [ Department of Marine Life Science, Jeju National University ]
  • Jin Hee Kim [ Department of Veterinary Medicine and Applied Radiological Science Institute, Jeju National University ]
  • Eunjin Park [ Department of Veterinary Medicine and Applied Radiological Science Institute, Jeju National University ]
  • Yoon Kyu Lim [ Department of Veterinary Medicine and Applied Radiological Science Institute, Jeju National University ]
  • You-Jin Jeon [ Department of Marine Life Science, Jeju National University ]
  • Youngheun Jee [ Department of Veterinary Medicine and Applied Radiological Science Institute, Jeju National University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

이 권호 내 다른 논문 / Food Science and Biotechnology Volume 18 Number 6

    피인용수 : 0(자료제공 : 네이버학술정보)

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