Earticle

초록

영어

In this study, Korean mistletoe extract (KM-110) was fermented with two strains of Lactobacillus (FKM-110) and then toxicity, lectin content, and immune activities were investigated. The lectin content of FKM-110 was about 53- 71% lower than that of KM-110. When mice were subcutaneously administered with KM-110 and FKM-110, the LD50 obtained for KM-110 treatment was 50-100 mg/kg as compared to 150-200 mg/mL for FKM-110. Each preparation stimulated macrophages directly and enhanced productivity of inflammatory cytokines such as TNF-α and IL-1β. FKM- 110 treatment resulted in lower cytokine production compared to KM-110. When mice were immunized with Keyhol limpet hemocyanin (KLH) antigen along with KM-110 or FKM-110 administration, higher antibody titers to KLH were observed in the KM-110 or FKM-110 groups compared to mice immunized with KLH alone, thereby showing no difference between KM-110 and FKM-110. Therefore, fermentation of Korean mistletoe extract with these Lactobacillus strains decreased toxicity in vivo while the enhancement of immune activity by KM-110 and FKM-110 was similar. These data suggest that KM-110 fermentation tended to decrease lectin content and in vivo toxicity. In addition, other components in the fermented mistletoe extract appear to stimulate immuno-adjuvant activity instead of lectin.

목차

Abstract
 서 론
 재료 및 방법
 결과 및 고찰
 요 약
 문 헌

키워드

저자

• 윤택준 [ Taek Joon Yoon | 유한대학 식품영양과 ]
• 양웅석 [ Woong Suk Yang | 한동대학교 생의학연구소 ]
• 박성민 [ Sung Min Park | 한동대학교 생의학연구소 ]
• 정희윤 [ Heo Yune Jung | 한동대학교 생의학연구소 ]
• 이안나 [ An Na Lee | 유한대 식품영양과 ]
• 정진혁 [ Jin Hyuk Jung | 한동대학교 생의학연구소 ]
• 강태봉 [ Tae Bong Kang | 한동대학교 생의학연구소 ]
• 유영춘 [ Yung Choon Yoo | 한동대학교 생의학연구소 ]
• 김종배 [ Jong Bae Kim | 한동대학교 생의학연구소 ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국식품과학회지 [Korean Journal of Food Science and Technology]

• 간기

  격월간

• pISSN

  0367-6293

• 수록기간

  1969~2011

• 십진분류

  KDC 574 DDC 664