Earticle

초록

영어

Gromwell (LE, Lithospermum erythrorhizon), a perennial herbal plant, has been used for the treatment of various problems associated with atopic dermatitis of the skin, such as water loss, epidermal hyperproliferation, and severe inflammation. Previously, it was shown that oral supplementation with a 70% ethanol extract of gromwell prevented the development of atopic dermatitis in NC/Nga mice. In this study, in order to identify the fraction that mediates gromwell’s efficacy, the dietary effects of water and ethyl acetate fractions from the ethanol extract of gromwell were assessed in the development of dermatitis using NC/Nga mice. Dietary supplementation of the hot water fraction significantly reduced scores for epidermal hyperproliferation in parallel with a marked increase of ceramides. Supplementation of the gromwell hot water fraction also decreased scratching behavior, which was accompanied by a decrease in plasma levels of IgE. These results showed that the hot water fraction of the gromwell ethanolic extract prevented the development of atopic dermatitis by increasing ceramides in NC/Nga mice.

목차

Abstract
 서 론
 재료 및 방법
 결과 및 고찰
 요 약
 문 헌

키워드

저자

• 김영란 [ Young Ran Kim | 경희대학교 공서의학대학원 의학영양학과 ]
• 조시영 [ Si Young Cho | (주)아모레퍼시픽 기술연구원 ]
• 서대방 [ Dae Bang Seo | (주)아모레퍼시픽 기술연구원 ]
• 김성한 [ Sung Han Kim | (주)뉴트렉스 ]
• 이상준 [ Sang Jun Lee | (주)아모레퍼시픽 기술연구원 ]
• 조윤희 [ Yunhi Cho | 경희대학교 공서의학대학원 의학영양학과 ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국식품과학회지 [Korean Journal of Food Science and Technology]

• 간기

  격월간

• pISSN

  0367-6293

• 수록기간

  1969~2011

• 십진분류

  KDC 574 DDC 664