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Protective Effects of Chlorella vulgaris Extract on Carbon Tetrachloride-induced Acute Liver Injury in Mice

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 SCOPUS 바로가기
  • 통권
    Volume 18 Number 5 (2009.10)바로가기
  • 페이지
    pp.1186-1192
  • 저자
    Hyun-Kyung Kim, Li Li, Hyeong-Seon Lee, Mi-Ok Park, Dinesh Bilehal, Wei Li, Yong-Ho Kim
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A112619

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원문정보

초록

영어
The purpose of this study was to evaluate the protective effects of Chlorella vulgaris extract (CVE) against carbon tetrachloride (CCl4)-induced hepatotoxicity in mice. The mice received silymarin (100 mg/kg), intragastrieally (i.g.) and CVE (50, 100, and 200 mg/kg, i.g.), respectively, every other day, for 4 weeks before CCl4 administration. Twenty-four hr after the administration of CCl4, the serum and liver were analyzed. Our study found that in the CVE groups, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) levels had decreased significantly and the tissue injury was notably diminished compared to the CCl4 group. The antioxidant activities of CVE groups, such as superoxide dismutase (SOD), catalase, and glutathione (GSH), were significantly increased and the activity of nitric oxide synthase (NOS) was remarkably increased in a CVE concentration-dependent manner. In the CVE groups, cytochrome P450 2B1/2B2 (CYP2B1/2) content was decreased. These results indicate that CVE has protective effects against CCl4-induced hepatotoxicity via stimulation of the antioxidant activity and nitric oxide (NO) production, and through inhibition of CYP2B1/2.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 References

키워드

Chlorella vulgaris extract carbon tetrachloride (CCl4) antioxidant nitric oxide synthase (NOS) cytochrome P450 2B1/2B2

저자

  • Hyun-Kyung Kim [ Department of Biomedical Laboratory Science, Collge of Health, Gimcheon University ]
  • Li Li [ Department of Smart Foods and Drugs, Graduate School, Inje University ]
  • Hyeong-Seon Lee [ Department of Smart Foods and Drugs, Graduate School, Inje University ]
  • Mi-Ok Park [ Department of Pathology, Ulsan General Hospital ]
  • Dinesh Bilehal [ Department of Smart Foods and Drugs, Graduate School, Inje University ]
  • Wei Li [ Department of Smart Foods and Drugs, Graduate School, Inje University ]
  • Yong-Ho Kim [ Department of Smart Foods and Drugs, Graduate School, Inje University ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

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