Sung Hee Lee, Hea Young Oh, Jae Yoon Leem, Sun Yoon
언어
영어(ENG)
URL
https://www.earticle.net/Article/A112610
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원문정보
초록
영어
Acanthopanax senticosus has been used in East Asia as a traditional medicine. The purpose of this study is the investigation of an extraction method for A. senticosus var. subinermis (ASvS) leaves to improve their antioxidant and antiinflammatory activities. Six extracts were prepared: extracted with water (W), ethanol (Eth), water or ethanol after ultra high pressure (WP, EthP), and water or ethanol after an extrusion process (WEx, EthEx). Diphenylpicrylhydrazyl (DPPH) radical scavenging activity and ferric reducing ability showed that all extracts had a significant antioxidant activity. In anti-inflammatory activities, Eth and EthEx significantly inhibited the release of lipopolysaccharide (LPS)-induced nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-1β independent of cell viability in RAW 264.7 macrophage cells. Inducible NO synthase (iNOS) protein was significantly decreased by EthEx. These findings present that Eth and EthEx extracts of ASvS leaves have anti-inflammatory activities, and EthEx extract suppresses LPS-induced NO through the down-regulation of iNOS and proinflammatory cytokines.
목차
Abstract Introduction Materials and Methods Results and Discussion References
키워드
Acanthopanax senticosus var. subinermisantioxidantnitric oxideinducible nitric oxide synthaseextrusion
저자
Sung Hee Lee [ Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, College of Human Ecology ]
Hea Young Oh [ Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, College of Human Ecology ]
Jae Yoon Leem [ Department of Phamacy, College of Pharmacy, Woosuk University ]
Sun Yoon [ Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University, College of Human Ecology ]
Corresponding Author