CHANGES IN BODY AND ORGAN WEIGHTS,HEMATOLOGICAL PARAMETERS, ANDFREQUENCY OF MICRONUCLEI IN THEPERIPHERAL BLOOD ERYTHROCYTES OF ICRMICE EXPOSED TO LOW-DOSE-RATE -RADIATION
YU-MI KANG, HEE-SUN KIM, SUK-CHUL SHIN, YOUNG-WOO JIN
언어
영어(ENG)
URL
https://www.earticle.net/Article/A111566
원문정보
초록
영어
We exposed ICR mice to low-dose (0.2 Gy) and low-dose-rate (0.7 mGy/h) -radiation (137Cs) in the Low-dose-rateIrradiation Facility at the Radiation Health Research Institute to evaluate systemic effects of low-dose radiation. Wecompared the body and organ weights, number of blood cells (white and red blood cells and platelets), levels of biochemicalmarkers in serum, and frequency of micronuclei in polychromatic erythrocytes between low-dose irradiated and non-irradiated control mice. The ICR mice irradiated with total doses of 0.2 and 2 Gy showed no changes in body and organweights, number of blood cells (white and red blood cells), or frequency of micronuclei in the polychromatic erythrocytesof peripheral blood. However, the number of platelets (P = 0.002) and the liver weight (P < 0.01) were significantlyincreased in mice exposed to 0.2 and 2 Gy, respectively. These results suggest that a low-dose-rate of 0.7 mGy/h does notinduce systemic damage. This dose promotes hematopoiesis in the bone marrow microenvironment and the proliferationof liver cells. In the future, the molecular biological effects of lower doses and dose rates need to be evaluated.
목차
abstract 1. INTRODUCTION 2. MATERIALS AND METHODS 2.1 Animals 2.2 Irradiation 2.3 Body and Organ Weights 2.4 Measurement of White and Red Blood Cells andPlatelets 2.5 Measurement of Biochemical Markers in Blood 2.6 Micronuclei Analysis 2.7 Statistical Analysis 3. RESULTS 4. DISCUSSION 5. CONCLUSION REFERENCES
키워드
RadiationLow-dose-rateMiceOrgansBloodMicronuclei
저자
YU-MI KANG [ Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd. ]
SUK-CHUL SHIN [ Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd. ]
YOUNG-WOO JIN [ Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd. ]
HEE-SUN KIM [ Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd. ]
Corresponding author
대한방사선방어학회 [Korean Association For Radiation Protection]
설립연도
1975
분야
자연과학>기타자연과학
소개
회원 상호간의 협조와 친목을 도모함으로써 방사선방어에 관한 제반연구 및 발전에 이바지함을 물론 학술의 국제교류 및 국제학술단체와의 상호협력 증진에 기여함을 목적으로 하며, 이 목적을 달성하기 위하여 다음 각 호의 사업을 한다.
1. 방사선방어에 관한 학술연구발표회 및 강연회 등의 개최
2. 학회지 및 방사선방어에 관한 학술간행물의 발행 및 배포
3. 방사선방어에 관한 학술의 국제교류 및 협력
4. 방사선방어에 관한 국제학술자료의 조사, 수집 및 번역
5. 방사선방어에 관한 조사 및 연구용역
6. 회원의 연구활동을 위한 제반협조
7. 기타 본 학회의 목적 달성에 필요한 사항
간행물
간행물명
방사선방어학회지 [Journal of Radiation Protection and Research]