Chang Hyun Jin, Min Ah Kang, Young Man Lee, Yong Dae Park, Dae Seong Choi, Myung Woo Byun, Il Yun Jeong
언어
영어(ENG)
URL
https://www.earticle.net/Article/A110368
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원문정보
초록
영어
This study is to investigate the anti-inflammatory effects of the ethylacetate extract of Rehmannia glutinosa(RGEAE). The anti-inflammatory activities using nitric oxide (NO), cytokine, and chemokine production in lipopolysaccharide(LPS)-induced RAW 264.7 cells were checked. Results indicated that RGEAE suppressed the NO, interleukin-6 (IL-6), andmonocyte chemoattractant protein-1 (MCP-1) production in a dose-dependent manner. Inhibition of NO formation was due to adecrease in inducible NOS (iNOS) expression. It was also found that the anti-inflammatory activities of RGEAE resulted from itsinhibitory role on the nuclear factor (NF)-κB activation and reactive oxygen species (ROS) production. Therefore, it is suggestedthat RGEAE has potential as a therapeutic material to attenuate the inflammatory disease such as rheumatoid arthritis.
목차
Abstract Introduction Materials and Methods Results and Discussion References
키워드
Rehmannia glutinosanitric oxideinducible nitric oxide synthasenuclear factor-κBreactive oxygen species
저자
Chang Hyun Jin [ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580-185, Korea ]
Young Man Lee [ Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561-756, Korea ]
Min Ah Kang [ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580-185, Korea ]
Yong Dae Park [ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580-185, Korea ]
Dae Seong Choi [ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580-185, Korea ]
Myung Woo Byun [ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580-185, Korea ]
Il Yun Jeong [ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580-185, Korea ]
Corresponding author