Water Chestnut (Trapa japonica Flerov.) Exerts Inhibitory Effect on Postprandial Glycemic Response in Rats and Free Radical Scavenging Activity in vitro
Ming-Jung Kang, Soo-Kyung Lee, Ji-Hyun Song, Mi-Eun Kim, Myo-Jeong Kim, Jung-In Kim, Joung-Soon Jang, Jai-Hyun Lee
언어
영어(ENG)
URL
https://www.earticle.net/Article/A108275
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원문정보
초록
영어
The α-glucosidase inhibitory and antioxidant effects of water chestnut (Trapa japonica Flerov.) were assessed toexplore its possible use as an anti-diabetic agent. Methanol extracts of the fruit shell and meat of water chestnut were assayedfor inhibitory activity against yeast α-glucosidase and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity.Effect of fruit shell extract on postprandial glucose response was assessed. Compared with fruit meat, shell extract showedstronger inhibition against α-glucosidase with an IC50 of 273µg/mL. Oral administration of fruit shell extract (500mg/kg)significantly lowered the postprandial area under the glucose response curve to starch (1g/kg) in streptozotocin (STZ)-induceddiabetic rats (p<0.01). Compared with fruit meat, shell extract showed stronger scavenging activity against DPPH, with anIC50 of 27.1µg/mL. The results indicate that the fruit shell of water chestnut was effective in controlling postprandialhyperglycemia and exerted an antioxidant effect. Therefore, water chestnut may be useful in treating diabetes.
목차
Abstract Introduction Materials and Methods Results and Discussion References
Ming-Jung Kang [ Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University, Gimhae, Gyeongnam 621-749, Korea ]
Soo-Kyung Lee [ Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University, Gimhae, Gyeongnam 621-749, Korea ]
Ji-Hyun Song [ Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University, Gimhae, Gyeongnam 621-749, Korea ]
Mi-Eun Kim [ Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University, Gimhae, Gyeongnam 621-749, Korea ]
Myo-Jeong Kim [ Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University, Gimhae, Gyeongnam 621-749, Korea ]
Joung-Soon Jang [ College of Medicine, Chung-Ang University, Seoul 156-756, Korea ]
Jai-Hyun Lee [ Department of Genetic Engineering, Dong-A University, Busan 604-714, Korea ]
Jung-In Kim [ Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University, Gimhae, Gyeongnam 621-749, Korea ]
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