Earticle

초록

영어

Lysozyme was treated with digestive enzymes and the production of interleukin 8 (IL-8) was measured in Caco-2cell with the peptides from lysozyme upon stimulating with lipopolysaccharide (LPS) to investigate the overall anti-inflammatory activity of lysozyme when it is in digestive tracts. Lysozyme reduced IL-8 production, and the peptides frompepsin hydrolysis of lysozyme had the similar effect. The products of trypsin digestion of lysozyme had no effect on thereduction of IL-8 production while those of pepsin-trypsin hydrolysis did. The effectiveness of lowering IL-8 production wasnot different by time of the peptide addition. When Caco-2 cells were pre-incubated with peptides for 24 hr, the reductioneffects were observed from the peptides from pepsin hydrolysis, indicating that some of the peptides are still remaining in thecells. Therefore, it can be concluded that the IL-8 reduction effect of lysozyme against LPS still remained even after thepepsin and trypsin hydrolysis.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 References

키워드

저자

• Mooha Lee [ Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Korea ]
• Denise Young [ Department of Food Science, University of Guelph, Guelph, Ontario N1G 2W1, Canada ]
• Yoshinori Mine [ Department of Food Science, University of Guelph, Guelph, Ontario N1G 2W1, Canada ]
• Cheorun Jo [ Department of Animal Science and Biotechnology, Chungnam National University, Daejeon 305-764, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Food Science and Biotechnology

• 간기

  격월간

• pISSN

  1226-7708

• 수록기간

  1992~2009

• 십진분류

  KDC 574 DDC 664