Antioxidative Activity of Cherry Tomato (Lycopersicon lycopersicum var. cerasiforme) Extracts and Protective Effect for H2O2-induced Inhibition of Gap Junction Intercellular Communication
This study was performed to analyze various antioxidants, to evaluate the antioxidative activities, and to measurethe protective effect for gap junction intercellular communication (GJIC) to assess the functional potency of the cherry tomato.The ascorbic acid, lycopene, and β-carotene were measured at 503.4±9.6, 39.7±1.5, and 7.4±0.3mg/100g d.w., and α-, β+γ-,δ-tocopherol contents were measured at 8.3±0.1, 1.7±0.0, and 0.1±0.0mg/100g d.w., respectively. Cherry tomato extractusing hexane/acetone/EtOH (2:1:1, CTE) exhibited a ABTS radical scavenging activity with an IC50 value of 48.83±0.30µg/mL. The cherry tomato protected against the inhibition of GJIC induced by H2O2 in WB-F344 rat liver epithelial cells, and thereduction in phosphorylated Cx43 was most clearly correlated with the concentration of CTE. These results demonstrated thatthe cherry tomato harbors a wealth of potent antioxidants and might be protect human body against the inhibition of the GJICby toxic components.
목차
Abstract Introduction Materials and Methods Results and Discussion References
키워드
cherry tomatoantioxidantlycopenegap junction intercellular communication
저자
Suna Kim [ Food Function Research Group, Korea Food Research Institute, Seongnam, Gyeonggi 463-746, Korea ]
Won Hee Choi [ Food Function Research Group, Korea Food Research Institute, Seongnam, Gyeonggi 463-746, Korea ]
Jiyun Ahn [ Food Function Research Group, Korea Food Research Institute, Seongnam, Gyeonggi 463-746, Korea ]
Tae Youl Ha [ Food Function Research Group, Korea Food Research Institute, Seongnam, Gyeonggi 463-746, Korea ]
Corresponding author