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Effect of an Anabolic Steroid, Nandrolone Decanoate, on Aquaporin 1 and 9 Gene Expression in the Rat Epididymis

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  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    Reproductive & developmental biology 바로가기
  • 통권
    Volume 33 No 1 (2009.03)바로가기
  • 페이지
    pp.55-61
  • 저자
    Hee-Jung Seo, Hyo-Jin Kang, Inho Choi, Yong-Pil Cheon, Ki-Ho Lee
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A106306

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초록

영어
The epididymis in the male reproductive tract is the site where spermatozoa produced from the testis become mature. The epididymis is divided into 4 different segments, initial segment and caput, corpus, and caudal epididymis, depending upon functional and morphological features. Aquaporins (Aqps) are water channel molecules, which are present in the epididymis and play a major role in removal of epididymal water, resulting in creation of microenvironment for sperm maturation and concentration of sperms. Nandrolone decanoate (ND) is a synthetic anabolic-androgenic steroid, which is used to treat clinical diseases and improve physical ability and appearance. Even though it is well determined that the ND causes the male infertility by affecting the testis, little is known the effect of the ND on the epididymis. The present study was focused to examine the effect of ND at different treatment doses and periods on expression of Aqp1 and Aqp9 genes in the epididymis of pubertal rats. Results showed that mRNA expression of Aqp1 and Aqp9 genes among the parts of the epididymis was differentially regulated by ND treatment doses. In addition, treatment periods of ND caused differential expression of Aqp1 and Aqp9 mRNAs among segments of the epididymis. Therefore, it is believed that male infertility induced by ND could be resulted not only from malfunction of the testis but also from aberrant gene expression of Aqp1 and Aqp9 in the epididymis.

목차

ABSTRACT
 INTRODUCTION
 MATERIALS AND METHODS
  Animals and Treatment
  Collection of Tissues and RNA Isolation
  cDNA Synthesis and Real-Time Polymerase Chain Reaction(Real-Time PCR)
  Data Analysis
 RESULTS
  Expression of Aqp1 and Aqp9 in Initial Segment and Caput Epididymis
  Expression of Aqpl and Aqp9 in the Corpus and Caudal Epididymis
 DISCUSSION
 REFERENCES

키워드

Epididymis Aquaporin Nandrolone decanoate Anabolic steroid Male reproduction

저자

  • Hee-Jung Seo [ Department of Biochemistry and Molecular Biology and Eulji University Medical Sciences Research Institute,School of Medicine, Eulji Universtty ]
  • Hyo-Jin Kang [ Department of Biochemistry and Molecular Biology and Eulji University Medical Sciences Research Institute,School of Medicine, Eulji Universtty ]
  • Inho Choi [ School of Biotechnology, Yeungnam Univeristy ]
  • Yong-Pil Cheon [ School of Life Sciences and Chemistry, Institute of Basic Sciences, Sungshin Women's University ]
  • Ki-Ho Lee [ Department of Biochemistry and Molecular Biology and Eulji University Medical Sciences Research Institute,School of Medicine, Eulji Universtty ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    Reproductive & developmental biology
  • 간기
    계간
  • pISSN
    1738-2432
  • eISSN
    2288-0151
  • 수록기간
    1977~2018
  • 십진분류
    KDC 527 DDC 636

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