Jin Nyoung Ho, Hye Kyung Kim, Hong Yon Cho, Eun Jeong Lim
언어
영어(ENG)
URL
https://www.earticle.net/Article/A105499
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원문정보
초록
영어
Ultraviolet B (UVB) radiation provokes the generation of reactive oxygen species (ROS) in the cells and skin, whichinduce oxidative stress in the exposed cells, leading to photoaging and cancer. Using the human keratinocytes HaCaT cell line, weinvestigated the photoprotective effects of aucubin isolated from Eucommia ulmoides. Pretreatment with aucubin markedlysuppressed UVB-induced oxidative stress, which manifests as a decrease in intracellular lipid peroxidation, elevation of catalaseactivity, and reduced glutathione content. In addition, aucubin significantly reduced expression of matrix metalloproteinase-1(MMP-1) protein (54%) and mRNA. Taken together, these results suggest that aucubin may offer protection against UVB-induced oxidative stress and may be used as a potential agent in prevention of UVB-induced photoaging.
목차
Abstract Introduction Materials and Methods Results and Discussion References
키워드
photoagingultraviolet B (UVB)aucubinoxidative stressmatrix metalloproteinase-1 (MMP-1)
저자
Jin Nyoung Ho [ Department of Food and Biotechnology, Han-Seo University, Seosan, Chungnam 356-706, Korea ]
Hong Yon Cho [ Department of Food and Biotechnology, Korea University, Seoul 136-701, Korea ]
Eun Jeong Lim [ Department of Food and Nutrition, Hanyang Women’s College, Seoul 133-793, Korea ]
Hye Kyung Kim [ Department of Food and Biotechnology, Han-Seo University, Seosan, Chungnam 356-706, Korea ]
Corresponding author