Current tuberculosis (TB) treatment usually requires a long period to entirely remove bacteria within the body. Furthermore, active TB is generally treated with combinations of several antibiotics to reduce the risk of multi-drug resistance. It has been reported that essential oils are a good alternative to conventional TB antibiotics due to their excellent anti-TB activity and low toxicity within the body. Pulmonary delivery permits better exposure of drugs to the respiratory tissues and drugs can readily diffuse into the systemic circulation due to the presence of a large absorptive alveolar surface with a thin epithelial cell. In view of aerodynamics, it is regarded that the optimum size of particles should be 1~5 μm for efficient pulmonary delivery. In the present study, essential oils were encapsulated into poly(ethylene glycol) (PEG) particles using a supercritical particles from gas saturated solutions (PGSS) process. The effects of various operating conditions such as temperature, pressure, the content of essential oils and nozzle geometry on the morphology and encapsulation efficiency of essential oil loaded PEG particles were investigated in detail. Keywords : supercritical CO2 , PGSS , PEG , essential
키워드
supercritical CO2PGSSPEGessential oil
저자
Jin-Ah CHOI [ Department of Chemical and Biochemical Engineering, The University of Suwon, Korea. ]
In-Il JUNG [ Department of Chemical Engineering, Yonsei University, Korea. ]
Gio-Bin LIM [ Department of Chemical and Biochemical Engineering, The University of Suwon, Korea. ]
Jong-Hoon RYU [ Department of Chemical and Biochemical Engineering, The University of Suwon, Korea. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동