Earticle

초록

영어

Topical natural antioxidants are a useful strategy for the prevention of oxidative stress mediated
cardiovascular disease including atherosclerosis. From the viewpoint of this underlying principle, the screening of natural plant extracts with scavenging activity for pro-oxidant reactive species is a primary requirement for the development of new topical antioxidant formulations. PSORALEAE
SEMEN (PS) is pharmaceutical name and it’s botanical name is Psoralea corylifolia Linne. This
plant has been used as a traditional herbal medicine for the treatment of coronary artery disease,
reducing blood flow and leucopenia. It has been reported that the extract of PS has pharmacological activities such as being anti-aging, anti-cancer and hematogenous effect. In the present study, extracts from PS were evaluated for their putative in vitro scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite]. Moreover, we investigated the antioxidant activity by TEAC and DPPH assay and content of total phenolics as well as inhibitory effect on Cu2+-induced human LDL. The PS extracts presented a high potency to scavenge the tested ROS and RNS, as well as an inhibitory effect on LDL oxidation. In conclusion, the PS extracts have anti-oxidative and anti-atherosclerotic effects in vitro system, which can be used for developing pharmaceutical drug against oxidative stress and atherosclerosis. [This work was supported by the Dongguk University Research Fund and the MRC program of MOST/KOSEF (grant #: R13-2005-01001-0).]

키워드

저자

• Hye-Sook LEE [ Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University. ]
• Min-Ja LEE [ Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University. ]
• Hyun-Jung JUNG [ Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University. ]
• Hyuck KIM [ Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University. ]
• Sun-Dong PARK [ Cardiovascular Medical Research Center and Dept. of Prescriptionology, College of Oriental Medicine, Dongguk University. ]
• Won-Hwan PARK [ Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576