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Suppressive effect of FARFARE FLOS extracts on oxidative stress and inflammatory response through the antioxidative mechanism

첫 페이지 보기
  • 발행기관
    한국생물공학회 바로가기
  • 간행물
    한국생물공학회 학술대회 바로가기
  • 통권
    2009 춘계학술대회 및 국제심포지움 (2009.04)바로가기
  • 페이지
    pp.206-206
  • 저자
    Hye-Sook LEE, Min-Ja LEE, Hyun-Jung JUNG, Hyuck KIM, Won-Hwan PARK, Sun-Dong PARK
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A105428

※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.

원문정보

초록

영어
There is currently increased interest in the identification of antioxidant compounds that are
pharmacologically potent and have low or no side effects. Plants produce significant amounts
of antioxidants to prevent the oxidative stress caused by photons and oxygen, therefore they
represent a potential source of new compounds with antioxidant activity. FARFARE FLOS
(FF) has been frequently used on the respiratory system including bronchitis, phthisis. In
previous study, the antioxidant activity of extract from FF was studied in vitro methods by
measuring the antioxidant activity by TEAC, measuring the scavenging effects on ROS and
RNS as well as measuring the inhibitory effect on Cu2+-induced human LDL oxidation. The
FF extracts were found to have a potent scavenging activity, as well as an inhibitory effect on
LDL oxidation. And this study was designed to evaluate whether FFEA (ethyl acetate fraction
of FARFARE FLOS) may ameliorate oxidative stress and inflammatory status through the
antioxidative mechanism in LPS-stimulated RAW 264.7 murine macrophage cell line.
Treatment of RAW 264.7 cells with FFEA significantly reduced LPS-stimulated ROS
generation, NO production, iNOS mRNA level, expression of proinflammatory cytokine such
as IL-1β, IL-6, TNF-α and HO-1 in a dose-dependent manner. In conclusion, the FF extracts
have anti-oxidative and anti-inflammatory effects in vitro system, which can be used for
developing pharmaceutical drug against oxidative stress and atherosclerosis.[This work was
supported by the Dongguk University Research Fund and the MRC program of MOST/KOSEF (grant #: R13-2005-01001-0).]

키워드

FARFARE FLOS (FF) Antioxidative Anti-inflammatory HO-1 RAW 264.7 cells

저자

  • Hye-Sook LEE [ Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University. ]
  • Min-Ja LEE [ Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University. ]
  • Hyun-Jung JUNG [ Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University. ]
  • Hyuck KIM [ Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University. ]
  • Won-Hwan PARK [ Cardiovascular Medical Research Center and Dept. of Diagnostics, College of Oriental Medicine, Dongguk University. ]
  • Sun-Dong PARK [ Cardiovascular Medical Research Center and Dept. of Prescriptionology, College of Oriental Medicine, Dongguk University. ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
  • 설립연도
    1984
  • 분야
    공학>생물공학
  • 소개
    이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다 1. 생물공학 분야의 발전을 위한 연구 협력 2. 생물공학의 실용화를 촉진시키기 위한 산학 협동 3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최 4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간 5. 생물공학 발전을 위한 정책 건의 6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동

간행물

  • 간행물명
    한국생물공학회 학술대회
  • 간기
    반년간
  • 수록기간
    1985~2013
  • 십진분류
    KDC 476 DDC 576

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