Earticle

초록

영어

Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive immunoinflammatory mechanism are involved. Bee venom (BV) and melittin (Mel) have frequently been used as a remedy for inflammatory diseases. We studied whether BV and Mel have antiatherosclerotic effects. Atherosclerotic lesions were induced by lipopolysaccharide (LPS, conc. 2 mg/kg) intraperitoneally injection mice.
Mice were fed with an atherogenic diet containing 15% fat, 1.25% cholesterol and 0.5% cholic acid. BV and Mel treatment significantly reduced biochemical damage (total cholesterol, triglyceride levels) and significantly increased high-density lipoprotein (HDL) cholesterol levels in
atherosclerosis mice. Furthermore, BV and Mel decreased the expression of tumor necrosis factor (TNF)-α and interleukin (IL)-1β, vascular cell adhesion molecule (VCAM)-1, intercellular adhesion molecule (ICAM)-1, fibronectin and transforming growth factor (TGF)-β1 in atherosclerosis mice. These findings suggest that the anti-atherosclerotic effect of BV and
Mel in atherosclerosis mice and BV and Mel may have a protective effect against chronic inflammatory diseases.

키워드

저자

• Ki-Yeon PARK [ Department of Pathology, College of Medicine, Catholic University of Daegu, Korea, 705-718. ]
• Ji-Hyun PARK [ Department of Pathology, College of Medicine, Catholic University of Daegu, Korea, 705-718. ]
• Soo-Jung KIM [ Department of Pathology, College of Medicine, Catholic University of Daegu, Korea, 705-718. ]
• Kyung-Hyun KIM [ Department of Pathology, College of Medicine, Catholic University of Daegu, Korea, 705-718. ]
• Woo-Ram LEE [ Department of Pathology, College of Medicine, Catholic University of Daegu, Korea, 705-718. ]
• Kwan-Kyu PARK [ Department of Pathology, College of Medicine, Catholic University of Daegu, Korea, 705-718. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576