Earticle

초록

영어

The hyaluronic acid (HA) is a high-molecular weight, highly anionic glycosaminoglycan (GAG) and has a variety of diverse biological functions such as promotion of cell motility, regulation of cell-matrix adhesion, promoting proliferation. In the current study, it was investigated the preventive effect of hyaluronic acid (HA) pretreatment on acetaminophen (APAP) induced acute hepatotoxicity.The mice were divided into four groups as follows Group A - saline, Group B –saline + APAP, Group C – HA alone, Group D – HA + APAP. HA was given orally for 14 days at a dose of 80 mg/kg b.wt. and fasted for 24 h prior to APAP at a dose 500 mg / kg b.wt. intraperitoneally. The degree of acute hepatotoxicity was measured by aspartate aminotransferase (AST) and alanine aminotransferase (ALT). The expression of interferon – γ (IFN- γ) in serum tissue was quantified.The degree of acute hepatotoxicity was markedly lower in HA pretreated group. The expression of interferon – γ (IFN- γ) was also (P < 0.05) suppressed in HA pretreated group. To conclude suppression of IFN- γ expression may exert a protective role in acute hepatotoxicity of APAP.

키워드

저자

• Jong-il CHOI [ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute. ]
• Jae Kyung KIM [ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute. ]
• Jae Hun KIM [ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute. ]
• Beom-Suk SONG [ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute. ]
• Yohan YOON [ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute. ]
• Myung-Woo BYUN [ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute. ]
• Ju-Woon LEE [ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576